Abstract #2197

Metabolite Differences in Small Brain Regions between Mild Cognitive Impairment & Alzheimer Disease Patients by 3D Chemical Shift Imaging

Beatriz Martnez-Granados¹, M. Carmen Martinez-Bisbal^1,2, Vicente Belloch³, J. M. Lainez⁴, Begoa Lpez⁴, Miquel Baquero⁵, Joaquin Escudero⁶, Carol Guillem⁶, Bernardo Celda^1,2

¹Physical Chemistry, University of Valencia, Burjassot, Valencia, Spain; ²CIBER Bioengineering, Biomaterials & Nanomedicine. ISC III, Spain; ³MRI service, Hospital Universitario La Fe - ERESA, Valencia, Spain; ⁴Neurology Service, Hospital Clnico Universitario, Valencia, Spain; ⁵Neurology Service, Hospital Universitario La Fe, Valencia, Spain; ⁶Neurology Service, Hospital Universitario General, Valencia, Spain

Metabolic differences between patients with mild cognitive impairment (MCI) and Alzheimers disease (AD) by 3D CSI in small regions of parietal gray matter have been studied. 3D CSI (TE=31 ms) in a 3 T unit was performed in 54 MCI patients, 11 AD patients and 9 controls. Eight small voxels (0.75 cc) representatives of parietal gray matter were selected in two slices. NAA/Cr value was lower for AD patients than for DCL and controls in all voxels. NAA/Cr ratios were lower in the lower slice than in the upper slice. Cho/Cr ratios values also showed statistical differences between groups.