Hong Yang1, Xu-Ning Zheng2,
Yi-Lei Zhao3, Jue Wang4, Min-Ming Zhang5
1Department of Radiology,
First Affiliated Hospital of College of Medical Science, Zhejiang University,
Hangzhou, Zhengjiang, China, People's Republic of; 2Department of
Neurology, First Affiliated Hospital of College of Medical Science, Zhejiang
University, Hangzhou, Zhejiang, China, People's Republic of; 3Department
of Radiology, First Affiliated Hospital of College of Medical Science,
Zhejiang University, Hangzhou, Zhejiang, China, People's Republic of; 4State
Key Laboratory of Cognitive Neuroscience & Learning, Beijing Normal
University, Beijing, China, People's Republic of; 5Department of
Radiology, The Second Affiliated Hospital of College of Medical Sciences,
Zhejiang University, Hangzhou, Zhejiang, China, People's Republic of
Using regional homogeneity (ReHo) method, the current study explore the abnormal spontaneous neural activity of resting state in early PD patients. Ten early PD patients were compared with eleven controls. After data preprocessing, ReHo analysis was performed using software REST. The increased ReHo was showed in bilateral frontal lobe, left parietal lobe, left cerebellum, right parietal Lobe and precuneus; Meanwhile, the decreased ReHo was showed in left frontal Lob, left occipital lobe and calcarine. These results revealed the pathophysiological mechanisms underlying early PD and demonstrate the feasibility of using ReHo as a useful tool to monitor cerebral dysfunction in PD