Abstract #2172

Diffusion Tensor Parameters of the Optic Radiations Are Associated with Visual Acuity & Retinal Nerve Fiber Layer Loss Following Optic Neuritis

Robert a Bermel¹, Salim E. Abboud¹, Blessy Mathew², Ken E. Sakaie², Stephen E. Jones², Michael D. Phillips², Mark J. Lowe²

¹Neurological Institute, Cleveland Clinic, Cleveland, OH, United States; ²Imaging Institute, Cleveland Clinic, Cleveland, OH, United States

Transsynaptic degeneration may occur in response to demyelinating disease, and may represent a future therapeutic target for neuroprotection in MS. We use optic neuritis as a model system to identify transsynaptic changes in the visual pathways, using multimodal imaging.