Abstract #2156

In Vivo Kurtosis Imaging in Murine Cerebral Ischemia

Andreas Lemke¹, Saskia Grudzenski², Jrg Dpfert¹, Frederik Bernd Laun³, Tristan Kuder³, Marc Fatar², Lothar Rudi Schad¹

¹Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; ²Experimental Neurology, Heidelberg University, Mannheim, Germany; ³Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

Diffusion kurtosis imaging of eight mice with induced middle cerebral artery occlusion (MCAo) was performed 24 h after MCAo using a cryo probe and a 9.4 T animal scanner. The apparent diffusion coefficient (D_app=0.490.09 m/ms vs. 0.750.05 m/ms, P=0.0078), and the fractional anisotropy (FA=0.070.02 vs. 0.100.02, P=0.039) are significantly decreased in the ischemic tissue compared to the healthy contralateral tissue, whereas the kurtosis is significantly increased in the ipsilateral region (K_app=1.150.10 vs. 0.660.09, P=0.0078).