Abstract #2154

T2*-Weighted Signal Change of Oxygen Challenge as a Potential Better Penumbra EstimationA Transient Occlusion Study

Fang Du¹, Qiang Shen^1,2, Shiliang Huang¹, Timothy Q. Duong^1,2

¹Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; ²Ophthalmology/Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Mismatch of diffusion/perfusion by MRI has been used as an estimate of the ischemic penumbra, but there are large parts of the mismatch region appear not to at risk and it was also reported that some of the apparent diffusion coefficient reduction area can be salvaged by early reperfusion. We hypothesis that T2* weighted signal change following oxygen challenge could be used as an improved biomarker for penumbra. We tested this hypothesis on transient (45 mins) focal ischemia to determine.