Abstract #2150

Ischemic Brain Damage & Loss of Ion Homeostasis During Focal Ischemia

Fernando Emilio Boada¹, Edwin Nemoto², Yongxian Qian³, Costin Tanase³, Charles Jungreis⁴, Jonathan Weimer, Vincent Lee

¹Radiology & Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; ²Neurosurgery, University of New Mexico, Albuquerque, NM, United States; ³Radiology, University of Pittsburgh, Pittsburgh, PA, United States; ⁴Radiology, Temple University, Philadelphia, PA, United States

In this paper we use a non-human primate model of reversible focal ischemia to present evidence that elevated tissue sodium concentration (>65mM) during focal cerebral ischemia increases the risk of infarction after tissue reperfusion.