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Abstract #2085

Validation of Diffusion Weighted Imaging of Cortical Anisotropy by Means of a Histological Stain for Myelin

Michiel Kleinnijenhuis1,2, Kees Jan Sikma1,3, Markus Barth2,4, Pieter Dederen1, Valerio Zerbi1,5, Benno Ksters6, Dirk Ruiter1,2, Cornelis H. Slump7, Anne-Marie van Cappellen Van Walsum1,8

1Department of Anatomy, University Medical Centre St. Radboud, Nijmegen, Netherlands; 2Donders Institute for Brain, Cognition & Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands; 3Signals & Systems, Faculty of Electrical Engineering, Mathematics & Computer Science, University of Twente, Enschede, Netherlands; 4Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany; 5Department of Radiology, University Medical Centre St. Radboud, Nijmegen, Netherlands; 6Department of Pathology, University Medical Centre St. Radboud, Nijmegen, Netherlands; 7Signals & Systems, Faculty of Electrical Engineering, Mathematics & Computer Science, University of Twente, Enschede, Netherlands; 8MIRA Institute for Biomedical Technology & Technical Medicine, University of Twente, Enschede, Netherlands


We report on a pilot study aimed to validate Diffusion Weighted Imaging (DWI) of cortical anisotropy by means of a histological stain for myelin (LFB)in ex vivo human brain tissue samples.