Magne Mrk Kleppest1,2, Oliver Marcel
Geier1, Christopher Larsson1, Frederic Courivaud1,
Raimo Aleksi Salo1, Petter Brandal3, Inge Andre
Rasmussen1, Atle Bjornerud1
1Interventional Centre,
Oslo University Hospital, Oslo, Norway; 2Dept. of Physics, Univ.
of Oslo, Oslo, Norway; 3Dept. of Oncology, Oslo University
Hospital, Oslo, Norway
T2*-effects in blood from a single bolus injection of gadolinium based contrast agents can be significant even when short TE heavily T1-weighted sequences are used. We investigated the effect of T2*-shortening on the measured permeability related parameters obtained from standard two-compartment modeling with vascular deconvolution by applying a double echo 3D-saturation recovery (SR) DCE sequence with a TR of 3.3 sec. Both the transfer constant (Ktrans) and plasma volume (Vp) were found to be significantly over-estimated when T2*-effects were not considered in the dose-response calculation and the error was largest for Vp