Abstract #2051

Early Time Point Perfusion Imaging: Estimating Tissue Transit Time Directly from the Data Time Course

Kenneth K. Kwong¹, Ona Wu¹, Suk-Tak Chan¹, Koen Nelissen¹, David A. Chesler¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

In MR perfusion analysis, the tissue mean transit time τ is normally estimated indirectly by using the ratio of regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF). We propose two different methods to estimate τ directly using signals from the tissue contrast agent bolus concentration time course.