Emma Essock-Burns1,2, Joanna J. Phillips3,4,
Janine M. Lupo2, Soonmee Cha2,5, Susan M. Chang5,
Sarah J. Nelson1,6
1UCSF/UCB Joint Graduate
Group in Bioengineering, University of California San Francisco, San
Francisco, CA, United States; 2Department of Radiology &
Biomedical Imaging, University of California San Francisco, San Francisco,
CA, United States; 3Department of Pathology, University of
California San Francisco; 4Department of Laboratory Medicine,
University of California San Francisco, San Francisco, CA, United States; 5Department
of Neurological Surgery, University of California San Francisco, San Francisco,
CA, United States; 6Department of Bioengineering & Therapeutic
Sciences, University of California San Francisco, San Francisco, CA, United
States
Glomeruloid vasculature, a hallmark of GBM tumors, is associated with breakdown of the blood-brain barrier. During DSC-imaging this results in extravasation of contrast, causing challenges for accurate perfusion assessment. 35 flip angle DSC acquisition is one strategy for mitigating this competing effect. This study correlated complex vasculature from 22 GBM biopsies to DSC-perfusion parameters acquired with either 35 or 60 flip angle. Percent signal recovery inversely correlated with presence of complex vasculature across the study population and for the subset of data acquired with 35 flip angle. This study supports that complex vasculature can be well studied with 35 DSC-imaging.