Abstract #1978

A Patient-Specific Global Residue Function Improves Reproducibility in Longitudinal Monitoring of Perfusion Changes in Low-Grade Gliomas

Atle Bjornerud^1,2, Kim Mouridsen³, Kyrre Eeg Emblem^4,5

¹Interventional Centre, Oslo Univeristy Hospital, Oslo, Norway; ²Dept. of Physics, Univ. of Oslo, Oslo, Norway; ³Center for Functionally Integrative Neuroscience, Aarhus University Hospital, Denmark; ⁴A. A. Martions Center for Biomedical Imaging,, Massachusetts General Hospital; ⁵Oslo Univeristy Hospital, Norway

We present a method for improved reproducibility of DSC-MRI based perfusion measurements through the generation of a global patient specific tissue residue function obtained at a single time-point using an automatically generated AIF. The global scan-specific tissue response is then combined with the global residue function and the initial AIF to reconstruct a scan-specific AIF used to derive perfusion parameters at each time-point. The method was tested in the analysis of unaffected brain tissue in glioma patients undergoing multiple longitudinal scans and was found to significantly improve reproducibility of perfusion measurements compared to using scan-specific AIFs.