Abstract #1971

An Improved Quantification Method to Characterize Cerebral Hemodynamic Changes after Carotid Endarterectomy Surgery: A Dynamic Susceptibility Contrast MRI Study.

David E. Crane¹, Bradley J. MacIntos^1,2, Ediri Sideso³, James Kennedy³, Ashok Handa⁴, Manus J. Donahue⁵, Peter Jezzard⁵

¹Heart & Stroke Foundation Centre for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; ²Medical Biophysics, University of Toronto, Toronto, ON, Canada; ³Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; ⁴Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom; ⁵Clinical Neurology, FMRIB Centre, University of Oxford, Oxford, United Kingdom

A method of calculating quantitative DSC, thereby permitting longitudinal comparison, is demonstrated and applied to patients undergoing carotid endarterectomy surgery. Quantification was performed with the bookend technique, where T1-weighted steady-state measurement of CBV is used to scale DSC-derived absolute CBF values. Subcortical grey matter CBF results agreed with reported values and age trends. Comparison of pre vs. post surgery showed low inter-session variability and significant surgery effects. Thus, the DSC-bookend approach may be useful in characterizing the interaction between hemodynamics and CEA effects thereby helping to identify patients most likely to benefit from surgery.