Samdeep Mouli1, Noam Belkind1,
Weiguo Li1, Jason Sandberg1, David Magill1,
Rachel Klein1, Daniel Procissi1, Jodi Nicolai1,
Yang Guo1, Andrew Larson1, Reed Omary1
1Radiology, Northwestern
University,
We describe a novel locoregional technique, termed electro-nanotherapy, to increase the intra-tumoral uptake of dual imaging and therapeutic nanoparticles through tissue electroporation. Our results demonstrate the procedure results in a 6 fold increase in liver tumor nanoparticle uptake over conventional systemic delivery. Furthermore, using high resolution MRI T2 and T2* maps, we are able to assess the real-time biodistribution of these nanoparticles non invasively.