Abstract #1762

Enhanced Intra-Operative Control During Cryoablation by using the PRF Method: In Vivo Imaging & Histopathologic Correlation

Eva Rothgang^1,2, Wesley D. Gilson², Steffi Valdeig³, Li Pan², Jrg Roland⁴, Aaron Flammang², Christine H. Lorenz², Frank Wacker³, Bernd Frericks⁵

¹Pattern Recognition Lab, University Erlangen-Nuremberg, Erlangen, Germany; ²Center for Applied Medical Imaging, Siemens Corporate Research, Baltimore, MD, United States; ³Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University, Baltimore, MD, United States; ⁴Siemens Healthcare, Erlangen, Germany; ⁵Department of Radiology & Nuclear Medicine, Universittsmedizin BerlinCharit Campus Benjamin Franklin, Berlin, Germany

For enhanced intra-operative control during cryoablation, we propose to online monitor the procedure using the proton resonance frequency method (PRF). By monitoring temperatures in close proximity to the region being ablated, procedure safety and efficacy can be increased. The purpose of this study was to demonstrate the value of online PRF temperature monitoring to 1) estimate the pattern of ice ball growth between multiple cryoprobes; and 2) prevent injury to adjacent structures. In this study, PRF imaging during in vivo cryoablation of porcine kidney was compared to post-ablation imaging and histopathology.