Abstract #1690

Synthesis & Evaluation of PARACEST MRI Contrast Agents Containing an Amino Acid Arginine

Mojmir Suchy^1,2, Alex X. Li², Mark Milne¹, Robert Bartha², Robert H. E. Hudson¹

¹Chemistry, University of Western Ontario, London, Ontario, Canada; ²Robarts Research Institute, University of Western Ontario, London, Ontario, Canada

A new synthetic methodology for the preparation of Tm3+-derived PARACEST MRI contrast agents containing an amino acid arginine has been developed. The CEST sensitivity of these molecules has been evaluated and found to be comparable to that of Tm3+ DOTAM-Gly-Lys-OH, a PARACEST MRI contrast agent previously detected in mouse kidneys and mouse brain tumours.