Abstract #1563

Relationship of Basal Cerebral Blood Flow, Thickness of Cortical Gray Matter & Fractional Anisotropy of Cerebral White Matter in Adolescents

Ai-Ling Lin¹, Peter Kochunov¹, Peter T. Fox¹, Amy Ramage¹, Hsiao-Ying Wey¹, Timothy Q. Duong¹, Douglas Williamson²

¹Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States; ²Department of Psychiastry, University of Texas Health Science Center, San Antonio, TX, United States

The purpose of the study was to determine the relationship between the basal cerebral blood flow (CBF), cortical gray matter thickness (GMT) and white matter myelination in adolescents using MRI methods. Our results showed that gray matter pruning and white matter myelination occurred in parallel and the CBF reduction was mainly contributed by the reduced rate of myelination.