Wafaa Zaaraoui1, Simon Konstandin2,
Armin M. Nagel3, Tobias Wichmann4, Dominik Berthel4,
Sylviane Confort-Gouny1, Patrick J. Cozzone1, Bertrand
Audoin1,5, Jean Pelletier1,5, Lothar R. Schad2,
Jean-Philippe Ranjeva1
1CRMBM UMR CNRS 6612, Marseille,
France, Metropolitan; 2Computer Assisted Clinical Medicine,
Heidelberg University, Mannheim, Germany; 3Department of Medical
Physics in Radiology, Heidelberg, Germany; 4Rapid Biomedical GmbH,
Rimpar, Germany; 5Ple de Neurosciences Cliniques, Service de
Neurologie, Hpital de La Timone, Marseille, France, Metropolitan
This study aims to compare total sodium signals (tNa) from the various brain compartments (whitte matter (WM) and grey matter (GM)) obtained in healthy controls with those in the normal appearing WM, GM and WM lesions of a patient suffering from multiple sclerosis (MS). Explorations were performed on a 3T Verio Siemens system with a 8-element 23Na receive coil using a 3D density adapted radial projection pulse sequence (TE=550s). Elevated tNa signals were evidenced in all brain compartments of the patient. This preliminary study suggests that 23Na MRI is a promising marker of diffuse pathophysiological occurring in MS.