Abstract #1491

Chemical Shift Sodium Imaging of the Rat Brain During TmDOTP5- Infusion

Patrick Michael Heiler¹, Saema Ansar², Saskia Grudzenski², Friedrich Wetterling¹, Simon Konstandin¹, Stephen Meairs², Marc Fatar², Lothar Rudi Schad¹

¹Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany; ²Experimental Neurology, Heidelberg University, Mannheim, Germany

The paramagnetic lanthanide chemical shift agent TmDOTP^5- is used in chemical shift imaging experiments and the technique is applied to an animal model of stroke model. It could be shown that TmDOTP5- induces a large hyperfine shift crossing neither the cell membrane nor the blood brain barrier. In ischemia, induced by occlusion of the MCA, TmDOTP^5- shifts parts of the total sodium signal which indicates a disruption of the blood brain barrier.