Abstract #1483

Biomechanical Property Quantification of Prostate Cancer by Quasi-Static MR Elastography at 7 Telsa of Radical Prostatectomy & Correlation with Whole Mount Histology

Deirdre Maria McGrath¹, Warren D. Foltz¹, Navid Samavati¹, Jenny Lee¹, Michael A. Jewett², Theodorus H. van Der Kwast³, Cynthia Mnard¹, Kristy K. Brock^1,4

¹Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada; ²Department of Surgical Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada; ³Department of Pathology, University Health Network, Toronto, Ontario, Canada; ⁴Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada

Magnetic resonance elastography (MRE) holds enormous potential as a tool to guide prostate intervention for cancer, such as targeted radiation therapy, MRI-guided biopsy or high dose rate (HDR) brachytherapy. However, to assist in vivo method development quantitative data on the relative increase in biomechanical stiffness of prostate cancer above that of normal tissue is required. A high resolution quasi-static MRE method at 7 tesla has been applied to prostatectomy tissue for which the disease burden was assessed using whole-mount histology. The results revealed a high sensitivity of Youngs modulus to cancer and a strong correlation with pathology.