In Vivo L-COSY MRS of Healthy Brain & Glioblastoma

Saadallah Ramadan¹, Ovidiu C. Andronesi², Peter Stanwell¹, Alexander Lin¹, Gregory A. Sorensen², Carolyn Mountford¹

Acquisition and post processing parameters have been developed to allow, at 3T with a 32 channel head coil, an L-COSY to be acquired from the brain in 11 minutes. Cross peak assignments and relative ratios of metabolites in the healthy brain were recorded and statistically significant differences were recorded between healthy brain and glioblastoma. Good spectral resolution of the in vivo L-COSY allowed comparison with COSY from cultured cell lines.