Quantification of Glycine in the Human Brain by PRESS at 3T

Changho Choi¹, Sandeep Ganji¹

Glycine (Gly) in the healthy human brain has been measured at 3T using an optimized PRESS echo time, (TE1, TE2) = (60, 100) ms, which permitted detection of both Gly and myo-inositol (mI) with comparable selectivity. Metabolite concentrations were estimated with respect to the brain water concentration obtained from the GM and WM fractions within the voxel. From five normal subjects, the Gly and mI concentrations in the right parietal cortex were estimated to be 0.60.1 mM and 4.30.4 mM (meanSD, n=5), with mean CRLBs of 91% and 51%, respectively.