Abstract #1348

Improved Clinical Performance of a New Myocardial Adenosine Stress Perfusion Technique with SW-CG-HYPR at 3.0T: A Comparison to Conventional IR-Turbo-FLASH Perfusion MRI & X-Ray Angiography in Patients with Suspected Coronary Artery Disease

Heng Ma¹, Lan Ge², Jing An³, David Chen², Lixin Jin⁴, Xiaoming Bi⁵, Renate Jerecic⁴, Kuncheng Li¹, Debiao Li^2,6

¹Xuanwu Hospital, Capital Medical University, Beijing, China, People's Republic of; ²Northwestern University; ³Siemens Healthcare, MR Collaboration NE Asia, Siemens Mindit Magnetic Resonance; ⁴Siemens Healthcare, MR Collaboration NE Asia, Siemens Limited China; ⁵Siemens Healthcare, Cardiovascular MR R&D, USA; ⁶Cedars-Sinai Medical Center and UCLA

Conventional myocardial perfusion MRI is limited by the low spatial coverage (3 to 4 slices), temporal and spatial resolution, signal-to-noise ratio, and cardiac motion-related image artifacts. A sliding-window conjugate-gradient HYPR (SW-CG-HYPR) technique allows increased spatial coverage (whole left ventricular coverage), resolution, signal-to-noise ratio and reduced motion artifacts. This work shows that myocardial adenosine stress perfusion MRI with SW-CG-HYPR is feasible and robust in a clinical population. Compared with conventional IR-Turbo-FLASH perfusion MRI, perfusion imaging with SW-CG-HYPR allows whole left ventricular coverage and has higher diagnostic accuracy in patients with suspected CAD.