Li-Yueh Hsu1, Peter Kellman1,
Peter Gatehouse2, Sven Zuehlsdorff3, Christopher B.
Glielmi4, Andrew E. Arai1
1National Heart Lung &
Blood Institute, National Institutes of Health, Bethesda, MD, United States; 2CMR
Unit, Royal Brompton Hospital, London, United Kingdom; 3CMR
Research & Development, Siemens Medical Solutions, Chicago, IL, United States; 4CMR Research
& Development, Siemens Medical Solutions, Chicago, IL, United States
While it has been previously shown that myocardial perfusion reserve (MPR) is less sensitive to the nonlinearity of the arterial input function (AIF), using a single-bolus method to quantify myocardial blood flow (MBF) substantially overestimates MBF compared with either dual-bolus or dual-sequence methods.