Accelerating Global Cardiac Function Assessment in Mice using Compressed Sensing

Tobias Wech¹, Angela Lemke², Debra Medway², Lee-Anne Stork², Craig A. Lygate², Stefan Neubauer², Herbert Kstler¹, Jrgen E. Schneider²

Cine-MRI is a well-established tool to assess global cardiac function in rodent models of cardiovascular disease. The aim of this study was to validate compressed sensing as an approach to accelerate cine-MRI in mice at 9.4T. Fully sampled data cine sets acquired in normal and chronically infarcted mice were 2-, 2.5-, 3- and 4-fold undersampled in post-processing and subjected to compressed sensing reconstruction. Blinded segmentation of all data showed that 3-fold acceleration is possible without impairing accuracy of left-ventricular volume and mass measurements.