Abstract #1143

Morphological & Metabolic Characterization of a New Model of Spinal Cord Injury Without Reloading using 1H MRI & 31P NMR Spectroscopy

Celine Baligand¹, Ravneet S. Vohra², Fan Ye², Jonathon Keener³, Wootaek Lim², Sean Charles Forbes², Prithvi K. Shah², Prodip Bose^3,4, Glenn A. Walter¹, Floyd Thompson^3,4, Krista H. E. Vandenborne²

¹Physiology & Functional Genomics, University of Florida, Gainesville, FL, United States; ²Physical Therapy, University of Florida, Gainesville, FL, United States; ³North Florida/South Georgia Veterans Health System of Florida, Gainesville, FL, United States; ⁴Departments of Physiological Science & Neurology, University of Florida, Gainesville, FL, United States

MRI and dynamic 31P spectroscopy were used to characterize morphology and function in a new rat model of muscle atrophy with incomplete spinal cord injury (SCI) combined to cast immobilization (IMM). We demonstrated that IMM prevented muscle recovery due to reloading, and show slower phosphocreatine recovery after exercise in SCI animals.