Modeling the Effect of Diffusion on the Assessment of Ktrans & ve in DCE-MRI

Stephanie Lynne Barnes^1,2, John C. Gore^1,2, Thomas E. Yankeelov^1,2

DCE-MRI allows for the estimation of tumor tissue parameters by modeling contrast agent kinetics using the standard (Tofts) model. However, cases exist in which the analysis results in parameter values that are not physically relevant. It has been hypothesized that the reason for this is diffusion that occurs in poorly perfused tissues. To investigate the possible effect of diffusion, we developed a 2D finite element model of CA concentration in the tissue as described by diffusion and CA delivery through a centralized vessel. Results indicate that diffusion effects can account for the physically irrelevant parameter estimations of the standard model.