Feasibility of Dual Pharmacokinetic Modeling using Gd-DTPA/MRI & 18F-FDG/PET

ric Poulin¹, tienne Croteau¹, Rjean Lebel¹, Luc Tremblay¹, Roger Lecomte¹, M'Hamed Bentourkia¹, Martin Lepage¹

The purpose of this study was to evaluate the correspondence between the AIF derived from MRI and PET, and to determine whether the AIF obtained by one modality can be converted into the AIF for the other modality. We showed that Gd-DTPA and ¹⁸F-FDG AIF were not identical but that using a bi-exponential model, we were able to convert Gd-DTPA AIF to ¹⁸F-FDG AIF, and vice versa. No statistical difference was found between area under the curve of experimental and converted curves. Results suggest that it would be possible to perform dual kinetic modeling using MRI and PET.