Anti-Angiogenic Therapy Follow-Up in a Mouse Tumor Model by a Novel 3D Radial Multi-Gradient Echo DCE MRI Technique with Individual AIF Measurement

Nadine El Tannir El Tayara^1,2, Nidhal Ben Achour^1,2, Christine Walczak^1,2, Fariba Nemati³, Joel Mispelter^1,2, Didier Decaudin³, Julien Vautier^1,2, Andreas Volk^1,2

The purpose of this work was to evaluate a new quantitative DCE-MRI technique combining 3D tumor imaging with interleaved high time resolution 2D heart imaging (AIF) in a context of treatment follow-up. We investigated its ability to assess early change of microvascular parameters under anti-angiogenic therapy (Sunitinib) and showed a histograms K^trans distribution shift towards lower values at day 4 after treatment initiation. Significant decrease in K^trans median and mode values was observed, as well as tumor growth inhibition over the 11 days treatment period. Results were compatible with a predictive value of these Ktrans parameters for anti-angiogenic treatment response.