Using DCE-MRI Data to Constrain & Simplify PET Kinetic Modeling

Jacob U. Fluckiger¹, Xia Li¹, Jennifer Whisenant¹, Lei Xu¹, Junzhong Xu¹, Todd E. Peterson¹, John C. Gore¹, Thomas Yankeelov¹

Quantitative PET modeling is made difficult by the inability to separate tissue time activity curves into their constituent compartments. DCE-MRI modeling could be used in conjunction with dynamic PET imaging to overcome this limitation. The fractional volume parameters measured from a DCE-MRI scan can be used to separate tissue time activity curves and simplify PET modeling.