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Abstract #1048

Combining Amide-Proton-Transfer MRI with DCE-MRI to Improve Prostate Cancer Detection

Guang Jia1, Ronney Abaza2, Joanna D. Williams3, Debra L. Zynger3, Jinyuan Zhou4, Zarine K. Shah1, Mitva Patel1, Steffen Sammet1, Lai Wei5, Robert R. Bahnson2, Michael V. Knopp1

1Wright Center of Innovation in Biomedical Imaging & Department of Radiology, The Ohio State University, Columbus, OH, United States; 2Department of Urology, The Ohio State University, Columbus, OH, United States; 3Department of Pathology, The Ohio State University, Columbus, OH, United States; 4Department of Radiology, Johns Hopkins University, Baltimore, MD, United States; 5Center for Biostatistics, The Ohio State University, Columbus, OH, United States


APT-MR imaging was first applied to the prostate in this feasibility study and the initial experience from 12 prostate cancer patients reveals increased MR imaging-detectable mobile proteins in cancerous regions of the prostate.