Abstract #1037

Distinction of Invasive Lobular Carcinoma, Invasive Ductal Carcinoma & Healthy Breast Tissue In Vivo with L-COSY at 3T

Saadallah Ramadan¹, Hayden Nicholas Box¹, Pascal Baltzer², Alexander Lin¹, Peter Stanwell^3,4, Eva Gombos¹, Werner a Kaiser², Carolyn Mountford¹

¹Radiology, Brigham & Women's Hospital, Boston, MA, United States; ²Radiology, Institute of Diagnostic & Interventional Radiology, Jena, Germany; ³School of Health Sciences, The University of Newcastle, Newcastle, NSW, Australia; ⁴Radiology, Brigham & Womens Hospital, Boston, MA, United States

This pilot study investigates changes to lipid chemistry in the breast that occur with invasive cancer, using Localized COrrelated SpectroscopY (L-COSY). Early results indicate that the COSY method distinguishes lobular from ductal carcinoma and from healthy breast tissue based on the chemical shift of the resonance in the 3.00-3.30ppm region and the ratio of lipid peak volumes .