Utility of Pre-Treatment MR Derived Vascular, Shape & Texture Parameters in the Prediction of Response to Neoadjuvant Chemotherapy in a Cohort of Breast Cancer Patients

Martin D. Pickles¹, Peter Gibbs¹, Martin Lowry¹, Lindsay W. Turnbull¹

Biomarkers of treatment response are currently being sought. Lesion shape, enhancement and kinetic curve assessment have been used to aid in the classification of breast lesions. These imaging features may also help to highlight potential poorer responders. The aim of this work was to determine if there were any associations between pre-treatment MR derived descriptors and response to neoadjuvant chemotherapy (NAC). The final LRA model indicated that patients with baseline characteristics of positive ER status and elevated texture parameters f2 (contrast) and f5 (inverse difference moment) are more likely to have residual disease at the end of NAC.