Abstract #0996

Effects of Downmodulation of Choline Kinase on MRS Choline Profile & Transcriptome in Ovarian Cancer Cells

Anna Granata¹, Egidio Iorio², Maria Teresa Comito¹, Alessandro Ricci², Maria Elena Pisanu², Zaver M. Bhujwalla³, Franca Podo², Silvana Canevari¹, Delia Mezzanzanica¹, Marina Bagnoli¹

¹Fondazione IRCCS Ist. Nazionale Tumori, Milano, Mi, Italy; ²Cell Biology & Neurosciences, Istituto Superiore di Sanit, Roma, RM, Italy; ³John Hopkins University, Baltimore, MA, United States

Detection and characterization by magnetic resonance spectroscopy of altered phosphatidylcholine metabolism in epithelial ovarian cancer (EOC) could provide choline-based imaging approaches as powerful tools to improve diagnosis and identify new therapeutic targets.