Abstract #0994

Multiparametric MR Mapping of Tissue Response to Photodynamic Therapy in an Intramuscular Model of Murine Squamous Cell Carcinoma

Mirabelle Sajisevi^1,2, David A. Bellnier³, Nestor Rigual², Mukund Seshadri^1,4

¹Preclinical Imaging Facility, Roswell Park Cancer Institute, Buffalo, NY, United States; ²Head & Neck Surgery, Roswell Park Cancer Institute, Buffalo, NY, United States; ³Cell Stress Biology, Roswell Park Cancer Institute; ⁴Pharmacology & Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, United States

The biological response of tumors to photodynamic therapy (PDT) is complex and involves a combination of cell kill, vascular damage, and induction of immune/inflammatory responses, all of which result in varying changes in contrast on MR images. In this study, we examined the utility of MRI in monitoring tissue response to PDT in an invasive, intramuscular model of squamous cell carcinoma. Our results demonstrate the potential value of MRI as a tool to monitor PDT-induced tissue damage in vivo.