Kun Qing1, Grady Wilson Miller2,3,
Talissa Altes2, Jaime F. Horta Coelho Mata2, Eduard E.
De Lange2, William A. Tobias3, Gordon D. Cates3,
James R. Brookeman2, John Philip Mugler1,2
1Biomedical Engineering,
University of Virginia, Charlottesville, VA, United States; 2Radiology,
University of Virginia; 3Physics, University of Virginia
Use of an SLR pulse for phase-based transmitter calibration is predicted to provide more accurate results than those from hard or Fermi pulses, especially for a range of off-resonance values and relatively low peak B1. For transmitter calibration prior to hyperpolarized He3 lung imaging, this approach showed good agreement with an established amplitude-based method. In contrast to the amplitude-based method, the phase-based method uses only a small fraction of the available hyperpolarized magnetization and requires less than 100 ms, and thus could be prepended to a lung-imaging pulse sequence, obviating the need for a dedicated calibration.