Jeff D. Winter1,2,
1Physiology & Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Research & Development, IMRIS, Winnipeg, Manitoba, Canada; 3Imaging Division, Lawson Research Institute, London, Ontario, Canada; 4Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 5Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
The injury or loss of renal microvessels is a determinant of renovascular disease severity. Assessment of renal microvasculature may be achieved using MR perfusion techniques including quantitative DCE and ASL. This study compared renal perfusion estimates for ASL and DCE MRI. DCE MRI was performed with a dual-bolus contrast injection for improved arterial input sampling. We found DCE estimates of renal cortex perfusion (3.57 0.96 ml/g/min) were in agreement with ASL (3.28 0.59 ml/g/min). Moreover, this study showed feasibility of the dual bolus approach for quantitative DCE for the first time outside of cardiac imaging.