Abstract #0771

Calibration & Validation of TRUST MRI for the Estimation of Cerebral Blood Oxygenation

Hanzhang Lu¹, Feng Xu¹, Ksenija Grgac^2,3, Peiying Liu¹, Qin Qin^2,3, Peter van Zijl^2,3

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; ²Department of Radiology, Johns Hopkins University, Baltimore, MD, USA; ³F.M. Kirby Center, Kennedy Krieger Institute, Baltimore, MD, USA

Recently, a T2-Relaxation-Under-Spin-Tagging (TRUST) MRI technique was developed to quantitatively estimate blood oxygenation (Y) via the measurement of pure blood T2. However, a human validation study has not been conducted. Here we used in vitro blood experiments to determine a 3-dimentional calibration plot in which blood T2 is a function of both Y and Hct. We further showed that, during hypoxia, Ya measured with PulsOx was 84.03.6% (N=7), while Ya derived from TRUST blood T2 and in vitro calibration plot was 83.73.6%. Furthermore, a significant correlation was observed between these two measures across subjects (P=0.05).