Abstract #0702

Tensor Based Morphometry on the Tc1 Mouse Model of Down Syndrome Highlights Previously Undetected Phenotypes

Benjamin Sinclair^1,2, Jon Cleary², Marc Modat¹, Francesca Norris^2,3, Frances Wiseman⁴, Victor Tybulewicz⁵, Elizabeth Fisher⁴, Mark Lythgoe², Sebastien Ourselin¹

¹Centre for Medical Image Computing, UCL, London, United Kingdom; ²Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom; ³Centre for Mathematics & Physics in the Life Sciences & Experimental Biology (CoMPLEX); ⁴UCL, Institute of Neurology, London, United Kingdom; ⁵MRC National Institute for Medical Research, London, United Kingdom

This study investigates the neurological characteristics of the Tc1 mouse model of Down syndrome using tensor based morphometry.