Abstract #0669

In Vivo Monitoring of Anti-Inflammatory Atorvastatin-Effects in Reperfused Myocardial Infarction using Integrated Cellular Fluorine 19F-MRI & 1H-Cardiac MRI

Yu-Xiang Ye¹, Thomas Christian Basse-Luesebrink¹, Paula Arias², Thomas Kampf¹, Vladimir Kocoski³, Elisabeth Bauer², Kai Hu², Valerie Jahns⁴, Peter M. Jakob^1,5, Karl-Heinz Hiller^1,5, Roland Jahns², Wolfgang Rudolf Bauer²

¹Department for Experimental Physics 5, University of Wrzburg, Wrzburg, Bavaria, Germany; ²Department of Internal Medicine I, University Hospital Wrzburg; ³Institute for Virology & Immunobiology; ⁴Institute for Pharmacology & Toxicology, University of Wrzburg; ⁵MRB Research Center, Magnetic Resonance Bavaria

In acute myocardial infarction (MI) blood monocytes play a key role in wound healing. Non-invasive imaging strategies are required to better understand and translate this knowledge into clinics. We investigated the value of integrating 19F-MRI cell trafficking with 1H-cardiac MRI to monitor an anti-inflammatory therapeutic approach of Atorgastatin in a MI rat model. The combined 19F/1H MRI found reduced myocardial monocyte infiltration and revealed a possible mechanism of action by Atorvastatin. Our platform provides a novel view on tissue injury and its innate immune response after ischemia-reperfusion, and thus contribute to gain new insights of anti-inflammatory therapy in MI.