Abstract #0632

Dynamic Magnetic Resonance Multi-Projection Inverse Imaging (Mini) with Isotropic Spatial Resolution

Kevin Wen-Kai Tsai¹, Aapo Nummenmaa², Thomas Witzel^2,3, Wei-Tang Chang⁴, Wei-Jui Kuo⁵, Fa-Hsuan Lin^1,2

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; ²A. A. Martinos Center, Massachusetts General Hospital, Charlestown, MA, USA; ³Harvard-MIT Divisions of Health Sciences & Technique, Charlestown, MA, USA; ⁴Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; ⁵Cognitive Neuropsychology Laboratory, National Yang-Ming University, Taipei, Taiwan, Taiwan

MR inverse imaging (InI) can achieve 100 ms temporal resolution with whole-brain coverage using highly parallel detection at the cost of compromised spatial resolution due to solving ill-posed inverse problems in image reconstruction. Here we propose the multi-projection InI (mInI) method. Using projection data in three orthogonal directions from all RF channels separately can achieve a high temporal resolution without compromising spatial resolution. Results of using mInI to study the hemodynamic responses in human visuomotor system from 12 participants using a 32-channel head coil array at 3T can achieve 100 ms temporal resolution and 4 mm3 isotropic spatial resolution.