Abstract #0618

Quantitative Assessment of Aldosterone-Induced Myocardial Fibrosis by Cardiac Magnetic Resonance

Mao-Yuan Su¹, Vin-cent Wu^2,3, Yen-Hung Line^2,3, Hsi-Yu Yu⁴, Wen-Yieh Isaac Tseng^1,5

¹Medical Imaging, National Taiwan University Hosptial, Taipei, Taiwan; ²Internal Medicine, National Taiwan University Hosptial, Taipei, Taiwan; ³TAIPAI study group; ⁴Sugery, National Taiwan University Hosptial, Taipei, Taiwan; ⁵Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan

We used quantitative late gadolinium enhancement (LGE) to detect microscopic myocardial fibrosis and study its relationships with the chamber stiffness of the left ventricle (LV). As compared to the normal subjects, patients with primary hyperaldosteronism (PA) had significantly increased enhancement value (EV) (0.450.07 vs. 0.350.09; p=0.016). The EV was significantly correlated with the plasma aldosterone level (r=0.48; p=0.031) and tdec (index of chamber stiffness derived from cine MRI; r= -0.55; p=0.042). In conclusion, quantitative LGE MRI can indicate the degree of microscopic myocardial fibrosis in PA. The measured index of myocardial fibrosis has functional impact on the LV diastolic function.