MRI & MRS Characterization of Two Experimental Models of Ovarian Cancer with Different Glycolytic Phenotypes

Rossella Canese¹, Giorgia Nardo², Marika Crescenzi², Egidio Iorio¹, Stefano Indraccolo²

We investigate by in vitro and in vivo 1H MRS two experimental models of ovarian cancer with different glycolytic phenotypes based on measurements of glucose consumption and lactate production rates in vitro as well as assessment of expression levels of glycolysis-associated genes. Metabolic differences have been detected between the two cell lines as well as the two in vivo models, notably in the lactate content. These differences were associated with tumour morphology and internal composition detected by MRI and ADC. These results could highlight a link between the Warburg effect and the response to anti angiogenic therapy in ovarian cancer.