Abstract #0532

Measuring the Volumes & Thickness of Hippocampal Subfields In Vivo using Automatic Segmentation of T2-Weighted MRI: A Pilot Evaluation Study

Paul A. Yushkevich¹, Hongzhi Wang¹, John Pluta¹, Sandhitsu R. Das¹, Brian Avants¹, Michael Weiner², Susanne Mueller², David Wolk³

¹PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA; ²Department of Radiology, University of California, San Francisco, San Francisco, CA, USA; ³Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA

High-resolution T2-weighted MRI has been shown to be a promising modality for imaging the subfields of the hippocampal formation. However, until now, the analysis of this data required tedious manual segmentation. We present a reliable method for automatic segmentation of hippocampal subfields in T2-weighted MRI and apply it to measure group differences in subfield volume and thickness between amnestic MCI patients and controls.