Abstract #0506

Simultaneous Acquisition of T1rho & T2 Quantification in Cartilage Reproducibility & Diurnal Variation

Xiaojuan Li¹, Joseph Schooler¹, Fei Liang¹, Keerthi Shet Vishnudas¹, Weitian Chen², Suchandrima Banerjee², Sharmila Majumdar¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; ²Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA

Magnetic resonance (MR) T1ρ and T2 relaxation time quantification can detect biochemical changes within cartilage collagen/proteoglycan matrix, and may provide complementary information associated with cartilage degeneration during osteoarthritis (OA). These techniques, however, normally need a long acquisition time. Furthermore, few studies have explored the potential diurnal variation in cartilage. The goals of this study were three fold: 1) To develop a sequence that combines T1ρ and T2 quantification; 2) To examine intra-day and inter-day reproducibility of the T1ρ and T2 quantification; 3) To examine the potential diurnal variation of T1ρ and T2 quantification in cartilage in young healthy adults.