Abstract #0463

Operatively Defined Ischemic Core, Penumbra & Oligemia in Human Acute Stroke using Sequential MR Perfusion Images

Hongyu An¹, Andria L. Ford², Cihat Eldeniz¹, Yang Yang¹, Yasheng Chen¹, Katie D. Vo³, William J. Powers⁴, Jin-Moo Lee², Weili Lin¹

¹Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; ²Neurology, Washington University in St. Louis, St. Louis, MO, USA; ³Radiology, Washington University in St. Louis, St. Louis, MO, USA; ⁴Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Tissue survival rate as a function of 3 hr and 6hr MTT prolongation revealed that distinct patterns of perfusion and subsequent perfusion changes can be utilized to separate tissue into ischemic core (MTT prolongation >15 seconds), penumbra (MTT prolongation: 5-15 seconds) and oligemia (MTT prolongation <5 seconds) using MR perfusion. Moreover, the more severely damaged tissue needs larger perfusion improvement to survive when compared to mildly injured tissue.