Functional Connectivity MRI Reveals Memory Networks After Maze Learning in Rodents

Fatima Ali Nasrallah¹, Chen Yow Der-Yow², Aryeh Routtenberg³, Kai-Hsiang Chuang

Functional connectivity MRI has emerged as a means to map intrinsic brain networks without the need of explicit tasks. We investigated mapping plasticity of the rodent brain after a memory task using Morris water maze. Extensive and enhanced connectivity was seen in trained rats compared to swim controls, and was maintained even seven days after training. This is the first demonstration of brain plasticity following a cognitive task can be detected in the anesthetized rat using functional connectivity MRI.