Abstract #0433

Caffeine Causes Widespread Decreases in Resting-State BOLD Connectivity & Energy

Chi Wah Wong¹, Valur Olafsson¹, Omer Tal¹, Thomas T. Liu¹

¹Center for Functional MRI, University of California San Diego, La Jolla, CA, USA

Previous studies have shown that caffeine reduces resting state BOLD connectivity in the motor cortex, regions in the default mode network, and the thalamus. In this study, we show that the caffeine-induced reductions in BOLD connectivity and energy are widespread, spanning multiple brain regions. Specifically, the mean network degree, which is a measure of the average number of links between brain regions, is significantly reduced by caffeine.