Abstract #0369

Macromolecular DCE MRI at 14.1Tesla Allows Comparative Quantitative Evaluation of Antiangiogenic Treatment Effects in Responsive & Resistant GBM Models

Myriam Marianne Chaumeil¹, Samuel Rose², Subramanian Sukumar¹, Hagit Dafni¹, Manish Aghi², Sabrina M. Ronen¹

¹Radiology, University of California San Francisco, San Francisco, CA, USA; ²Neurological Surgery, University of California San Francisco, San Francisco, CA, USA

Macromolecular dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) at 14.1Tesla was used to quantitatively measure the effect of antiangiogenic treatment with a Bevacizumab analogue in two glioblastoma (GBM) models: one responsive (U87) and one resistant (SF7796). Whereas no significant differences between GBMs were observed prior to treatment, antiangiogenic treatment induced a significant decrease in the mean values of permeability (PS, p=0.03) and blood volume fraction (fBV, p=0.001) in the responsive GBM model and no significant changes in the resistant one. Histogram analysis was also performed for both tumor types, allowing assessment of the heterogeneity of tumor response to treatment.