Reversal of ADC Changes in Tumors after Treatment at Short Diffusion Times

Junzhong Xu¹, Ke Li¹, Ralph Adam Smith¹, Ping Zhao¹, Mark D. Does¹, Henry Charles Manning¹, John C. Gore¹

In the current study, both the conventional pulse gradient spin echo (PGSE) and the oscillating gradient spin echo (OGSE) diffusion methods have been implemented to detect the tumor response to chemotherapy by Barasertib (AZD1152) at short diffusion times. The post-treatment ADCs obtained using OGSE at short diffusion times show an opposite change compared with those by PGSE, indicating tumor pathophysiological information at different length scales can be probed at different diffusion times. The results suggest that OGSE provides a different contrast to PGSE methods, and may provide a more specific means to monitor tumor early response to chemotherapy.