Comparison of Pseudocontinuous & Velocity Selective Arterial Spin Labeling with Gold Standard Xenon CT: A Study in Patients with Moyamoya Disease

Deqiang Qiu¹, Michael E. Moseley¹, Greg Zaharchuk¹

In this study, we compared the performance of 3D-FSE pseudocontinuous arterial spin labeling (pcASL) acquired at multiple post-label delay times and velocity-selective ASL (VSASL) in Moyamoya disease patients, who have known arterial transit arrival delay due to collateral networks. Stable xenon CT perfusion served as a CBF gold standard. Mean CBF differences and correlations were determined and compared. VSASL was shown to provide relatively more accurate absolute measurement of CBF values, though its correlation with xeCT measurement is not as strong as for pcASL due to overall lower SNR.